2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N6901
    Luteolin 7-sulfate 56857-57-9
    Luteolin 7-sulfate is isolated from Phyllospadix iwatensis Makino, a marine plant. Luteolin 7-sulfate attenuates TYR gene expression through the intervention of a cAMP-responsive element binding protein (CREB)- and microphthalmia-associated transcription factor (MITF)-mediated signaling pathway, leading to the decreased melanin synthesis.
    Luteolin 7-sulfate
  • HY-N6912
    Regelidine 114542-54-0 98.08%
    Regelidine is a natural product isolated from the stems of Tripterygium regelii.
    Regelidine
  • HY-N6913
    3α-Hydroxymogrol 1343402-73-2 99.88%
    3α-Hydroxymogrol is a triterpenoid isolated from Siraitia grosvenorii Swingle, acts as a potent AMPK activator, and enhances AMPK phosphorylation.
    3α-Hydroxymogrol
  • HY-N6920
    11-Oxomogroside IIIE 2096516-68-4 99.69%
    11-Oxomogroside IIIE is a cucurbitane triterpene glycoside isolated from Lo Han Kuo (Siraitia grosvenori).
    11-Oxomogroside IIIE
  • HY-N6922
    Danshenxinkun B 65907-76-8 99.89%
    Danshenxinkun B is an antioxidative component of tanshen (Salvia miltiorhiza Bung) .
    Danshenxinkun B
  • HY-N6923
    N-(3-Methoxybenzyl)oleamide 883715-21-7 99.24%
    N-(3-Methoxybenzyl)oleamide (MAC 18:1) is an individual macamide. N-(3-Methoxybenzyl)oleamide can be isolated from Lepidium meyenii (maca).
    N-(3-Methoxybenzyl)oleamide
  • HY-N7098
    Dihydrojasmone 1128-08-1 99.11%
    Dihydrojasmone, a constituent of bergamot oil, is an important perfume ingredient.
    Dihydrojasmone
  • HY-N7129
    Cinnamylideneacetic acid 1552-94-9 99.63%
    Cinnamylideneacetic acid is a photoresponsive compound which is capable of a photoinduced [2+2] cycloaddition.
    Cinnamylideneacetic acid
  • HY-N7130
    Thioisonicotinamide 2196-13-6 99.82%
    Thioisonicotinamide (4-Pyridylthioamide) is a synthetic intermediate used for pharmaceutical synthesis.
    Thioisonicotinamide
  • HY-N7150
    Tricetin 3',4',5'-trimethyl ether 18103-42-9 98%
    Tricetin 3',4',5'-trimethyl ether (5,7-Dihydroxy-3',4',5'-trimethoxyflavone) is a flavone glucoside, that can be isolated the flowers of Chrysanthemum sinensea. Tricetin 3',4',5'-trimethyl ether displays xanthine oxidase competitive-type inhibitory activity, with an IC50 of 0.51 μM and a Ki of 0.37 μM.
    Tricetin 3',4',5'-trimethyl ether
  • HY-N7206
    5-O-Methylvisamminol 80681-42-1 99.33%
    5-O-Methylvisamminol, a (furo) chromone identified in the extract of T. glauca, has a limited occurrence in the plant kingdom. 5-O-Methylvisamminol is useful in (chemical) phylogeny and is a possible excellent chemotaxonomic marker (family and/or subfamily level) for Apiaceae.
    5-O-Methylvisamminol
  • HY-N7258
    Neohesperidose 17074-02-1 98%
    Neohesperidose is a disaccharide isolated from species of typha.
    Neohesperidose
  • HY-N7390
    Cholesterol glucuronide 17435-78-8 99.58%
    Cholesterol glucuronide is an endogenous metabolite of lipid generated in the liver by UDP glucuonyltransferase.
    Cholesterol glucuronide
  • HY-N7483
    1-Dehydroxybaccatin IV 57672-78-3 98.0%
    1-Dehydroxybaccatin IV is a taxane diterpene. 1-Dehydroxybaccatin IV shows concentration-dependent NO inhibition, with an IC50 of 32.2 μM.
    1-Dehydroxybaccatin IV
  • HY-N7605
    11-epi-mogroside V 2146088-12-0 98.0%
    11-epi-mogroside V is a mogroside in the fruit of Siraitia grosvenori. 11-epi-mogroside V exhibits considerable bioactivity in promoting glucose uptake in human HepG2 cells in vitro.
    11-epi-mogroside V
  • HY-N7625
    N-Formylcytisine 53007-06-0 99.17%
    N-Formylcytisine is a cytisine-type alkaloid from the stem bark of Maackia amurensis.
    N-Formylcytisine
  • HY-N7661
    4β-Hydroxywithanolide E 54334-04-2 98%
    4β-Hydroxywithanolide E, isolated from Physalis peruviana L., inhibits adipocyte differentiation of 3T3-L1 cells through modulation of mitotic clonal expansion. 4β-Hydroxywithanolide E is an adipogenesis inhibitor and inhibits PPARγ, C/EBPα, and the adipocyte-specific molecule aP2 mRNA expression.
    4β-Hydroxywithanolide E
  • HY-N7668
    Neotheaflavin 36451-14-6 99.61%
    Neotheaflavin, from black tea, inhibits pancreatic lipase.
    Neotheaflavin
  • HY-N7702
    N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide 883715-23-9 99.48%
    N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide is a macamide isolated from Maca (Lepidium meyenii Walp.) N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide induces mesenchymal stem cells osteogenic differentiation and consequent bone formation through activating the canonical Wnt/β‐catenin signaling pathway. N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide can be used for the research of osteoporosis.
    N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide
  • HY-N7737
    Furan fatty acid F6 57818-36-7 98%
    Furan fatty acid F6 (3,4-dimethyl-5-pentyl-2-furanundecanoic acid) is an ester product.
    Furan fatty acid F6
Cat. No. Product Name / Synonyms Application Reactivity